TALRIA LIMITED DMCC • DUBAI, UAE

“Just breathing can be such a luxury at times.”

The Breakthrough in Non-Inflatable Supraglottic Airway Management

Home to the intellectual property and clinical biomechanics developed by renowned consultant anesthesiologist Dr. Muhammed Aslam Nasir (Macewen Medal Recipient). Powering i-gel® in human emergency medicine and v-gel® in species-specific veterinary anaesthesia across 100+ countries.

Modern operating theatre anaesthesia
Routine & Emergency Resuscitation100+ Countries
Anatomical Thermoplastic SealSub-5s Placement

Zero inflatable cuff. Zero mucosal capillary ischemia. Licensed globally to Intersurgical Ltd.

100+

Countries Deployed

Routine & emergency care
75M+

Procedures Worldwide

Human & veterinary patients
0 PSI

Cuff Inflation Trauma

Pressure-neutral soft gel seal
2016

Macewen Medal

Awarded to Dr. M.A. Nasir (DAS)
Clinical Environments & Frontline Practice

Where Dr. Nasir's Airway Inventions Protect Lives

Human Emergency Medicine & Veterinary Surgery
Hospital Operating Theatre
Operating TheatresRoutine & urgent elective general anaesthesia
Emergency Paramedic Resuscitation
Emergency & Paramedic ResuscitationJAMA AIRWAYS-2 trial gold standard
Veterinary Surgical Suite
Veterinary Operating SuitesTracheal rupture prevention with v-gel®
Biomedical Materials Laboratory
Biomedical EngineeringPrecision SEBS thermoplastic molding & QA
The Core Clinical Paradigm Shift

Inflatable Balloon Cuff vs. Non-Inflatable Anatomical Gel Seal

Dr. Muhammed Aslam Nasir recognized that conventional airway cuffs create hydrostatic pressures far exceeding mucosal capillary perfusion pressure, causing ischemic tissue trauma.

Conventional Inflatable Cuff (1st Gen LMA)HIGH MORBIDITY RISK

Balloon Compression and Distension

Standard supraglottic airways rely on air inflation through a pilot balloon. In clinical practice, overinflation occurs in over 80% of routine cases, creating pressures reaching 80–120 cmH2O.

MUCOSAL TISSUE CROSS-SECTIONCAPILLARY PERFUSION: ISCHEMIC SHUTDOWN
Laryngeal Mucosa & Nerve Fibres (Lingual / Hypoglossal)[Capillaries collapsed: > 40 cmH2O mucosal ischemia]INFLATABLE CUFF (85 cmH2O)Traumatic expansion against cartilaginous rings
Simulate Balloon Pressure:85 cmH2O
30 cmH2O (Min)40 cmH2O (Capillary Threshold)120 cmH2O (Max)
•Microvascular Ischemia: Capillary perfusion halts when pressure exceeds 30–40 cmH2O.
•Post-Operative Sore Throat: Documented in 30–55% of patients emerging from inflatable LMA.
•Nerve Palsies & Dysphagia: Direct compression of hypoglossal, lingual, and recurrent laryngeal nerves.
Dr. Nasir Innovation: i-gel® & v-gel®PHYSIOLOGICAL SAFETY

Pressure-Neutral Anatomic Gel Seal

Dr. Nasir eliminated the cuff entirely. Engineered from medical-grade SEBS thermoplastic elastomer, the seal mirrors human and veterinary anatomy, generating an airtight seal without mechanical tissue stress.

MUCOSAL TISSUE CROSS-SECTIONCAPILLARY PERFUSION: Least compression
Laryngeal Mucosa & Normal MicrocirculationANATOMICAL GEL SEAL (< 20 cmH2O)Natural contour seal • Zero pilot balloon • Zero mucosal compression
Mucosal Contact Pressure:< 20 cmH2O (Physiological Safe Zone)
Intact Capillary Perfusion: Mucosal blood flow is 100% maintained throughout surgery.
Insertion with-in 5 Second: No syringe, no manometer check, no cuff inflation calculations.
Superior laryngeal Seal: Consistently delivers >30 cmH2O seal pressure for ventilation.
Dual Biomedical Portfolios

Engineered for Human Critical Care & Veterinary Precision

Two revolutionary applications of Dr. Nasir’s patented supraglottic technology, each customized for anatomical physiology.

i-gel human anaesthesia
Human Clinical BenchmarkLicensed to Intersurgical

i-gel® Supraglottic Airway

Human Anaesthesia & Resuscitation

The 2nd Generation Supraglottic Airway with Non-Inflatable Perilaryngeal Anatomy Seal

The gold-standard non-inflatable supraglottic airway device used in routine anaesthesia, difficult airway algorithms, and emergency resuscitation worldwide.

Anatomical Non-Inflatable Cuff: Molded from medical-grade thermoplastic elastomer to conform naturally to the larynx, supraglottis, and piriform fossae without requiring air inflation.
Integral Gastric Channel: Separate esophageal tract allowing early diagnostic verification of tube placement, gastric suction, and venting of regurgitated stomach contents.
Integral Bite Block & Buccal Stabiliser: Protects airway patency against clenching while the widened lateral wings conform to the oropharyngeal curve, preventing rotation or accidental displacement.
Direct Intubation Conduit: Engineered inner lumen diameter facilitates fiberoptic-guided or blind passage of cuffed endotracheal tubes without removing the airway.
Sizes Available (Human Neonatal to Bariatric):
Size 1 (2 - 5 kg)Size 1.5 (5 - 12 kg)Size 2 (10 - 25 kg)Size 2.5 (25 - 35 kg)Size 3 (30 - 60 kg)Size 4 (50 - 90 kg)Size 5 (90+ kg)
Typical Seal Pressure> 30 - 35 cmH2O
Full i-gel® Technical Specs
v-gel veterinary anaesthesia
Veterinary Innovation PioneerPartner: Docsinnovent

v-gel® & v-gel® Advanced Veterinary Airway

Species-Specific Veterinary Anaesthesia

The World’s First Species-Specific Supraglottic Airway Devices for Veterinary Medicine

Species-specific anatomically contoured supraglottic airway device preventing tracheal trauma and delivering safe positive-pressure ventilation in veterinary anaesthesia.

Species-Specific Anatomical Bowl: Reverse-engineered from 3D CT reconstructions of feline, rabbit, and canine airways to mate seamlessly with the epiglottis, arytenoids, and pharynx.
Esophageal Sealing Plug: Distal tip gently occludes the upper esophageal sphincter to guard against gastric insufflation and passive regurgitation.
Low Dead Space & Low Airway Resistance: Super-wide internal airway channel decreases work of breathing in spontaneous ventilation while minimizing apparatus dead space.
Autoclavable & Reusable Engineering: Crafted from biocompatible medical silicone elastomer capable of withstanding dozens of autoclave sterilization cycles for cost-effective clinical adoption.
Species-Specific Variants (3D Anatomic Scan Fitted):
Feline C1 - C6 (0.8 - 7.0+ kg)Rabbit R1 - R5 (0.6 - 5.5 kg)Canine D1 - D6 (1.5 - 35+ kg)Equine Foals & Specialized
Autoclave ReusabilityUp to 40+ cycles (134°C)
Full v-gel® Veterinary Specs
Interactive Biomedical Schematic

i-gel® Anatomical Architecture & Seal Biomechanics

Click on any numbered anatomical marker or feature tag to inspect its engineering and clinical significance.

PATENT: US 7,464,710 B2SCALE: ANATOMICAL 1:1 MODELNON-INFLATABLE SEBS
15mm ISO9cm11cm13cm123456
Part 6DR. NASIR PATENT SPECIFICATION

Non-Inflatable Anatomical Gel Seal

Medical-grade SEBS | Pressure-neutral contact (<20 cmH2O) | Oropharyngeal seal >30 cmH2O

The core breakthrough invented by Dr. Muhammed Aslam Nasir: molded from soft medical-grade thermoplastic elastomer (SEBS) accurately mirroring perilaryngeal anatomy without air inflation.

Clinical & Biomechanical Advantage:

Creates an airtight seal (>30 cmH2O) matching aryepiglottic folds, pyriform fossae, and thyroid cartilage with zero cuff pressure, eliminating mucosal ischemia, nerve damage, and post-op sore throat.

Insertion Speed< 5 SecondsNo cuff inflation required
Oropharyngeal Seal> 30 cmH2OPositive pressure ventilation
Clinical Sizing & Airway Selection Guide

Interactive Airway Selector

Determine anatomical sizing, suction tube Fr, and airway parameters based on patient weight.

70 kg (154.3 lbs)
Min: 2 kgMax: 120+ kg
Presets:
Recommended Clinical Solution

i-gel® Medium Adult (Gold Standard)Size 4

Color CodingGreen
Oropharyngeal Seal Pressure> 32 - 38 cmH2O
Gastric / Suction Access12 Fr gastric catheter
ET Tube / Optical ConduitAccepts up to 7.0 mm ID tracheal tube
Clinical & Placement Guidance: Primary size deployed in emergency resuscitation and adult OR surgical procedures.
Executive Leadership & Board

The Visionaries Behind TALRIA LIMITED DMCC

A cohesive leadership team combining world-class clinical invention, precision biomedical engineering, multinational licensing, and corporate governance.

Managing Director & Chief InventorMBBS, FRCA • Consultant Anesthesiologist

Dr. Muhammed Aslam Nasir

"Just breathing can be such a luxury at times. Our purpose was simple yet profound: design an airway that mirrors human and animal anatomy so naturally that inflation, pressure trauma, and tissue ischemia become obsolete."

Dr. Muhammed Aslam Nasir is a world-renowned consultant anaesthesiologist, medical innovator, and the pioneering inventor behind the i-gel® human supraglottic airway device and the v-gel® species-specific veterinary airway system. With decades of frontline clinical experience in anaesthesia and critical care, Dr. Nasir revolutionized supraglottic airway management by discovering that an anatomically molded thermoplastic elastomer could replace traumatic inflatable balloons. In 2016, Dr. Nasir was awarded the prestigious Macewen Medal by the Difficult Airway Society (DAS, UK) for outstanding and lasting contribution to airway management. He also serves as President of Docsinnovent Ltd and is the founder of Light4Life, a philanthropic foundation providing emergency disaster relief and education.

Key Distinctions & Milestones:
Awarded the Macewen Medal by the Difficult Airway Society (DAS, UK) in 2016
Inventor of the Nasir Laryngeal Airway (i-gel®) licensed globally to Intersurgical
Inventor of v-gel®, the world’s first species-specific veterinary supraglottic device
Holds extensive patent families across USPTO, EPO, WIPO, and international registries
Dr. Muhammed Aslam Nasir

Dr. Muhammed Aslam Nasir

President, Docsinnovent Ltd

MD, TALRIA LIMITED DMCC

Macewen Medalist (2016)

Bestowed by the Difficult Airway Society (DAS) for transformative contributions to airway safety.

Talha Nasir
Director

Talha Nasir

COO

Talha Nasir serves as Chief Operating Officer (COO) across TALRIA LIMITED DMCC’s medical and veterinary portfolios. With a scientific foundation in marine biology and environmental sciences, he directs operational execution, regulatory compliance, quality management, and sustainable biomedical development. Working closely with international manufacturing partners and clinical research teams, he oversees operational strategy to ensure every generation of supraglottic device complies strictly with international directives (MDR 2017/745, ISO 13485, and US FDA requirements), uniting rigorous biological insight with high-precision global operations.

Leadership Scope:
Global operational strategy and cross-functional corporate execution
Biocompatibility validations, environmental standards & sustainable materials
Mr. Tuaha Nasir
Director

Mr. Tuaha Nasir

Director of Business Development

Mr. Tuaha Nasir spearheads international business development, strategic licensing alliances, and commercial channel expansion for TALRIA LIMITED DMCC. Managing corporate relationships with multinational medical device distributors, contract manufacturing partners, and clinical purchasing syndicates, Tuaha has been instrumental in scaling the commercial footprint of Dr. Nasir’s airway technologies across Europe, North America, the Middle East, and Asia. He also directs cross-border trade operations and serves as a director in family commercial enterprises and charitable initiatives including Light4Life.

Leadership Scope:
Multinational IP licensing structures and OEM manufacturer relations
Global distributor network expansion across 100+ healthcare jurisdictions
Mr. Adam Nasir
Director

Mr. Adam Nasir

Director of Business Development

Mr. Adam Nasir leads market penetration strategies, clinical education initiatives, and veterinary institutional integration for TALRIA LIMITED DMCC. He focuses on building long-term alliances with veterinary teaching hospitals, university anaesthesia departments, private veterinary clinic groups, and military medical academies. Adam’s market-building expertise drives rapid clinical adoption by demonstrating how the transition from cuffed endotracheal tubes to non-inflatable supraglottic airways dramatically lowers patient morbidity and accelerates surgical turnover.

Leadership Scope:
Veterinary hospital networks & corporate clinic group adoption
Clinical evidence dissemination & anaesthesiology symposium representation
Mr. Danyal Nasir
Director

Mr. Danyal Nasir

Financial Director

Mr. Danyal Nasir directs corporate finance, treasury operations, IP valuation, and fiscal governance for TALRIA LIMITED DMCC. Overseeing the enterprise’s financial architecture from the Dubai Multi Commodities Centre (DMCC) headquarters, Danyal coordinates cross-border royalty streams, investment allocation for clinical trials, tax-efficient IP asset stewardship, and compliance with UAE Free Zone and international statutory accounting standards. His stewardship provides the fiscal backbone that fuels continuous R&D and global patent protection.

Leadership Scope:
Corporate financial strategy & DMCC statutory governance
Intellectual property portfolio asset valuation and royalty optimization
Mr. Touseef Akhtar
General Manager

Mr. Touseef Akhtar

General Manager

Mr. Touseef Akhtar directs strategic operations, commercial development, and R&D pipelines for TALRIA LIMITED DMCC from the company's headquarters in the Dubai Multi Commodities Centre (DMCC). Bringing extensive multi-sector experience in Pharma, healthcare and medical device innovation, Mr. Akhtar leads the enterprise's research initiatives, product engineering roadmaps, and global clinical validation strategies. Working in alignment with the firm's fiscal and corporate governance framework—overseen by Company Directors —Mr. Akhtar coordinates cross-border technology transfers, regulatory compliance protocols, and commercialization pathways for advanced medical technologies. His leadership bridges scientific innovation with rigorous operational execution, driving the continuous development and global market introduction of proprietary medical devices.

Leadership Scope:
Directing overarching business operations, budgeting frameworks, and organizational compliance to meet strict UAE Free Zone and international regulatory standards.
Overseeing the commercial lifecycle and strategic value realization of proprietary medical technologies, clinical data assets, and global product innovations.
Multinational Commercial Reach

Global Adoption Across 100+ Healthcare Jurisdictions

From premier university operating theatres to frontline paramedic response in extreme environments.

Headquartered in DMCC Dubai, UAE
NETWORK: GLOBAL DISTRIBUTION100+ COUNTRIES ACTIVE
TALRIAIntersurgicalNorthEuropeanAsia-Pacific
Global IP & Corporate Governance

TALRIA LIMITED DMCC (Global Corporate Seat)

Dubai Multi Commodities Centre, Dubai, UAE

Authorized Regulatory Channels
CE Mark • US FDA 510(k) Cleared
100+Countries with active routine clinical use
Clinical Trials & International Guidelines

Backed by Multi-Center Trials & Resuscitation Protocols

Explore All Clinical Studies
JAMA (Journal of the American Medical Association) • 2018

Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest (AIRWAYS-2 Trial)

A landmark multicenter cluster-randomized clinical trial involving 9,296 adult patients with non-traumatic out-of-hospital cardiac arrest attended by 1,523 paramedics from four ambulance services in England.

Key Finding

Demonstrated high initial airway placement success rates for i-gel® (87.4% on first attempt), confirming its reliability as a frontline resuscitation airway in emergency medical systems.

British Journal of Anaesthesia • 2015

Difficult Airway Society 2015 Guidelines for Management of Unanticipated Difficult Intubation in Adults

The definitive guidelines for unanticipated difficult intubation in general anaesthesia. Specifies 2nd generation supraglottic airway devices with gastric channels as Plan B rescue devices.

Key Finding

Recommends second-generation supraglottic airways such as i-gel® for rescue oxygenation due to superior seal pressures and esophageal vent protection against aspiration.

Resuscitation • 2008

Size 4 i-gel Airway Insertion During Chest Compressions in a Manikin Simulation

Investigated the feasibility and speed of inserting an i-gel airway during continuous uninterrupted external cardiac compressions.

Key Finding

100% of insertions succeeded without interrupting CPR chest compressions, with median insertion times under 8 seconds.

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